药物相互作用对心脏药物的疗效和毒性都能产生一定影响。药物相互作用可发生在药物吸收和消除的部位,也可发生于起搏细胞、特殊传导组织和心肌的受体部位。为尽力减少药物不良反应对心脏病人的危害,要把心脏药物的动力学知识应用于临床。 Drug interactions can have some effect on the efficacy and toxicity of cardiac drugs. Drug interactions can occur at sites where drugs are absorbed and eliminated, as well as at the pacemaker cells, particularly conductive tissue, and at the receptor sites in the myocardium. In order to minimize the adverse effects of adverse drug reactions to heart patients, we should apply the kinetic knowledge of cardiac drugs to clinical practice.