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目的探讨不同亚型HPV混合感染及分型与宫颈病变严重程度的关系。方法选取2012年1月至2015年1月于深圳市龙岗区第二人民医院进行HPV检测的妇女2 105例,其中,HPV感染阳性妇女417例,据同步宫颈病理活检结果将HPV感染阳性妇女分为三组,分别为宫颈炎组258例,宫颈上皮内瘤变(CIN)组137例,宫颈癌组22例,比较HPV感染阳性率及型别分布。结果本研究中HPV感染阳性患者417例,阳性检出率为19.81%,多重感染68例(16.31%),高危型感染206例(49.40%),低危型感染143例(34.29%),宫颈炎组以高危型感染为主(67.05%),CIN组以低危型感染为主(68.62%),宫颈癌组以高危型感染为主(63.63%),差异具有统计学意义(P<0.05);将单因素分析后结果有意义的型别纳入Logistic回归模型中,结果显示,16型HPV感染及58型HPV感染均为宫颈癌的危险因素,6型HPV感染及11型HPV感染均为CIN的危险因素。结论高危型HPV感染是加重宫颈疾病的重要因素,低危型HPV感染主要引起CIN的发生。
Objective To investigate the relationship between different subtypes of HPV infection and typing and the severity of cervical lesions. Methods A total of 2 105 women were enrolled in the Second People’s Hospital of Longgang District from January 2012 to January 2015. Among them, 417 were HPV-positive women. According to synchronous cervical biopsy results, HPV-positive women The three groups were 258 cases of cervicitis group, 137 cases of cervical intraepithelial neoplasia (CIN) group and 22 cases of cervical cancer group. The positive rate and type distribution of HPV infection were compared. Results In this study, 417 patients were positive for HPV infection, the positive rate was 19.81%, 68 cases (16.31%) were multiple infection, 206 cases (49.40%) were high-risk infection, 143 cases (34.29%) were low-risk infection, In the inflammation group, high-risk infection was the most common (67.05%), low-risk infection (68.62%) in the CIN group and high-risk infection in the cervical cancer group (63.63%), with statistical significance (P <0.05 ). The univariate analysis of the results of meaningful type into the Logistic regression model, the results showed that type 16 HPV infection and type 58 HPV infection are cervical cancer risk factors, type 6 HPV infection and type 11 HPV infection are CIN risk factors. Conclusion High-risk HPV infection is an important factor in aggravating cervical diseases. Low-risk HPV infection mainly causes CIN.