论文部分内容阅读
目的探讨胎膜早破患者宫颈分泌物纤维连接蛋白(fFN)和外周血清粒细胞集落刺激因子(G-CSF)水平与绒毛膜羊膜炎的相关性。方法以107例胎膜早破患者为观察对象,根据有无绒毛膜羊膜炎及感染程度分为无绒毛膜羊膜炎组(A组)、亚临床绒毛膜羊膜炎组(B组)和临床绒毛膜羊膜炎组(C组),并以33例正常妊娠者为对照组。分别于产前采取外周静脉血和宫颈分泌物,于产后取胎盘组织,测定G-CSF和fFN水平。结果 A、B、C三组宫颈分泌物与胎盘组织fFN水平高于对照组,B组与C组明显高于A组,C组明显高于B组,差异均有统计学意义(P<0.05);胎膜早破者宫颈分泌物fFN水平与胎盘组织fFN水平呈正相关性(R~2=0.521,P<0.001)。A、B、C三组血清和胎盘组织的G-CSF水平高于对照组,B组与C组明显高于A组,C组明显高于B组,差异均有统计学意义(P<0.05);胎膜早破者外周血清G-CSF水平与胎盘组织G-CSF水平呈正相关性(R~2=0.865,P<0.001)。宫颈分泌物fFN和外周血清G-CSF水平对亚临床绒毛膜羊膜炎和临床绒毛膜羊膜炎的诊断价值有统计学意义(P<0.05)。结论宫颈分泌物fFN和外周血清G-CSF对亚临床阶段的绒毛膜羊膜炎有一定的预测价值,其普查对临床绒毛膜羊膜炎的防治有积极意义。
Objective To investigate the correlation between the level of fibronectin (fFN) and peripheral blood serum granulocyte colony stimulating factor (G-CSF) in patients with premature rupture of membranes and chorioamnionitis. Methods A total of 107 cases of premature rupture of membranes were enrolled. According to the presence or absence of chorioamnionitis and the degree of infection, the patients were divided into group A without chorioamnionitis, group B with subclinical chorioamnionitis and clinical villus Membranous amniotic membrane group (C group), and 33 cases of normal pregnancy as control group. Peripheral venous blood and cervical secretions were taken prenatally and placental tissues were taken from postpartum. The levels of G-CSF and fFN were measured. Results The levels of fFN in cervical secretions and placenta in groups A, B and C were significantly higher than those in control group, while those in group B and C were significantly higher than those in group A, while those in group C were significantly higher than those in group B (P <0.05) ). There was a positive correlation between fFN level in cervical secretions and placental fFN level (R ~ 2 = 0.521, P <0.001). The G-CSF levels in serum, placenta and placenta of group A, B and C were higher than those in control group, the levels of G-CSF in group B and C were significantly higher than those in group A, and the levels in group C were significantly higher than those in group B (P <0.05 ). There was a positive correlation between serum G-CSF level and placental G-CSF level in premature rupture of membranes (R ~ 2 = 0.865, P <0.001). Cervical secretions fFN and peripheral serum G-CSF levels of clinical diagnosis of subclinical chorioamnionitis and chorioamnionitis have statistical significance (P <0.05). Conclusions Cervical secretions fFN and peripheral serum G-CSF have certain predictive value for sub-clinical chorioamnionitis, and its screening has positive significance for the prevention and treatment of clinical chorioamnionitis.