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目的:研究单纯灌入不同烟龄人主流烟雾水溶液对小鼠的危害程度。方法:眼球取血,运用免疫透射比浊法检测小鼠血清中免疫球蛋白IgG、IgM水平;游离小鼠胸腺和脾脏,计算出小鼠胸腺指数和脾脏指数。结果:雌高烟龄组脾脏指数高于对照组(P<0.05),雄高烟龄组、雄中烟龄组胸腺指数均低于对照组,脾脏指数均高于对照组,但不具有统计学意义(P>0.05);雄低烟龄组、雌高烟龄组小鼠血清中IgM水平明显高于雄高烟龄组(P<0.05),但雄低烟龄组、雌高烟龄组IgG水平明显低于雄高烟龄组(P<0.05)。结论:烟龄越大的人,其主流烟雾水溶液可能对小鼠的危害越严重。
Aims: To study the degree of harm to mice caused by the simple injection of mainstream smoke aqueous solution of different smoking ages. Methods: The blood was collected from the eye and the serum immunoglobulin IgG and IgM levels were measured by immunoturbidimetry. The thymus and spleen of mice were dissociated and the thymus index and spleen index of mice were calculated. Results: The spleen index of female high smoking age group was higher than that of control group (P <0.05). The thymus index of male smoking age group and male smoking age group were lower than that of control group, but the spleen index was higher than that of control group (P> 0.05). The serum IgM level in male and female smoker group was significantly higher than that in male and female smoker group (P <0.05), but the male and female smoker group The level was significantly lower than the male smoking group (P <0.05). Conclusion: The older the smoker, the more mainstream tobacco smoke solution may be more harmful to mice.