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目的 :观察大承气冲剂对感染性腹膜炎的治疗作用及肠血流的影响。 方法 :采用盲肠末端结扎加穿孔的方法 ,制备腹腔感染家兔模型 ,分别给予大承气冲剂、先锋霉素Ⅵ和生理盐水。采用日本BMS株式会社制造的RBF Ⅰ型电解式血流量计 ,单本电极 ,电解电流为 5 0 μA ,电解时间为 2 0s。观察家兔回肠末端粘膜下血流变化。 结果 :腹膜炎家兔的肠血流量较正常家兔明显降低 ,腹膜炎家兔给予大承气冲剂后 30、6 0、90min肠血流量明显高于给药前 ,亦显著高于腹膜炎组和腹膜炎 +先锋霉素Ⅵ治疗组。与正常对照组家兔肠血流量无显著差异。 结论 :大承气冲剂可改善腹膜炎时组织缺血状况
Objective: To observe the therapeutic effect of Dachengqi Granules on infectious peritonitis and intestinal blood flow. Methods: Rabbit models of intraperitoneal infection were prepared by ligation of cecum and perforation of the cecum. Dachengqi granules, cephalosporin Ⅵ and saline were given respectively. RBF Ⅰ type electrolytic blood flow meter manufactured by Japan BMS Co., Ltd. was used as the single electrode. The electrolysis current was 50 μA and the electrolysis time was 20 s. Observed rabbit ileal submucosal blood flow changes. Results: The intestinal blood flow in rabbits with peritonitis was significantly lower than that in normal rabbits. The intestinal blood flow at 30, 60, 90 min after peritonitis rabbits was significantly higher than that before administration and also significantly higher than that in peritonitis and peritonitis + Pioneer ADM Ⅵ treatment group. There was no significant difference in intestinal blood flow between rabbits and normal control group. Conclusion: Dachengqi granules can improve tissue ischemia during peritonitis