对阿昔洛韦及相关药物(如泛昔洛韦、伐昔洛韦)的耐受常见于免疫缺陷患者,包括人免疫缺陷病毒(human immunodificiency virus,HIV)感染者及移植患者,很少发生于免疫功能正常的人群。该文对其耐药机制及流行病学研究进行简要的说明。阿昔洛韦、泛昔洛韦及伐昔洛韦是核苷类抗病毒药物。细胞摄取后,阿昔洛韦依靠病毒编码的胸苷激酶(thymidine kinase,TK)转化为阿昔洛韦单磷酸盐, To acyclovir and related drugs (such as famciclovir, valacyclovir) tolerance common in immunodeficient patients, including human immunodeficiency virus (human immunodificiency virus, HIV) and transplant patients, rarely occurs in immune function Normal crowd This article briefly describes its resistance mechanisms and epidemiological studies. Aciclovir, famciclovir and valacyclovir are nucleoside antiviral drugs. After cellular uptake, acyclovir relies on the virus-encoded thymidine kinase (TK) to convert acyclovir monophosphate,