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目的分析冠心病患者接受经皮冠状动脉介入治疗后引起支架内再狭窄的有关危险因素。方法 210例接受经皮冠状动脉介入治疗的冠心病患者,按照术后1年内冠状动脉造影结果将患者分为再狭窄组(50例)和非狭窄组(160例),分析引起患者支架内再狭窄现象发生的危险因素。结果两组患者吸烟、饮酒、高血压、糖尿病、心肌梗死史、置入支架数量、直径、支架长度等方面对比差异具有统计学意义(P<0.05)。两组患者总胆固醇、甘油三酯、脂蛋白a、总胆红素、纤维蛋白原和尿酸等水平对比差异具有统计学意义(P<0.05)。糖尿病、吸烟以及较高的血脂蛋白a、纤维蛋白原、尿酸水平是患者发生支架内再狭窄的危险因素(P<0.05)。结论冠心病患者在进行经皮冠状动脉介入治疗中应优先选择直径较大的支架,术后患者禁止吸烟,并合理控制血糖,降低自身脂蛋白、纤维蛋白原和尿酸的水平,由此来降低患者支架内再狭窄的发生。
Objective To analyze the risk factors of in-stent restenosis after percutaneous coronary intervention in patients with coronary heart disease. Methods A total of 210 patients with coronary heart disease undergoing percutaneous coronary intervention were divided into 2 groups: restenosis group (n = 50) and non-stenosis group (n = 160) according to coronary angiography within 1 year after operation. Risk factors for the occurrence of stenosis. Results The smoking, drinking, hypertension, diabetes mellitus, history of myocardial infarction, the number of stents inserted, the diameter and the length of stents were statistically significant (P <0.05). The differences of total cholesterol, triglyceride, lipoprotein a, total bilirubin, fibrinogen and uric acid between the two groups were statistically significant (P <0.05). Diabetes mellitus, smoking, and higher levels of serum lipoprotein-a, fibrinogen, and uric acid were risk factors for in-stent restenosis (P <0.05). Conclusion Patients with coronary heart disease should be treated with percutaneous coronary intervention with a larger diameter stent. No postoperative smoking should be given to patients with coronary heart disease, and their blood lipids should be controlled properly to reduce their levels of lipoproteins, fibrinogen and uric acid Restenosis in patients with stent.