多形核白细胞的存在对于肿瘤细胞的转移具有重要影响。该文以血液中的黑色素肿瘤细胞为例,模拟了其与附着血管壁面的白细胞之间的水动力相互作用。以往研究多将肿瘤细胞限于特定位置进行流场分析,该文采用了准定常方法,动态地描述了肿瘤细胞运动的过程。在不同的来流剪切率下,肿瘤细胞在与白细胞接触过程中的动力学特性会有所不同,且对肿瘤细胞最终的粘附结果产生影响。 The presence of polymorphonuclear leukocytes has a major impact on the metastasis of tumor cells. Taking the melanoma tumor cells in the blood as an example, this paper simulates the hydrodynamic interaction with leukocytes attached to the vascular wall. In the past, many researches limited the tumor cells to specific locations for flow field analysis. In this paper, quasi-routine method was used to describe the process of tumor cell movement dynamically. The kinetic properties of tumor cells during their contact with leukocytes will be different at different rates of shear flow and will have an impact on the final adhesion of the tumor cells.