目的:探讨应用Tei指数评价房间隔缺损(ASD)患者手术前后右心室功能的变化,评估介入及手术的近期疗效。方法:应用多普勒超声技术测定47例ASD(其中26例伴肺动脉高压)术前及术后3月的右室横径(RVDd)、右室射血分数(RVEF)、肺动脉收缩压(PASP)及Tei指数,25例健康成人作为对照组。结果:ASD患者的RVDd及右室Tei指数较正常对照组明显增大;肺动脉高压组的RVDd,ASD大小及右室Tei指数较无肺动脉高压组明显增大。经介入或手术治疗后,肺动脉高压阴性组患者右室Tei指数较术前降低,较对照组无统计学意义;肺动脉高压组右室Tei指数较术前降低,但仍较对照组大。结论:ASD患者右心功能有减退,介入及手术治疗对肺动脉高压阴性组患者右心功能改善近期疗效明显;对肺动脉高压组患者右心功能改善近期疗效不显著。 Objective: To evaluate the changes of right ventricular function in patients with atrial septal defect (ASD) before and after application of Tei index to evaluate the short-term effect of intervention and operation. Methods: The RVDd, RVEF and PASP were measured before and after operation in 47 patients with ASD (26 patients with pulmonary hypertension) by Doppler ultrasonography. ) And Tei index, 25 healthy adults as control group. Results: The RVDd and Tei index of right ventricle in ASD patients were significantly higher than those in normal controls. The RVDd, ASD and Tei index of right ventricle in pulmonary hypertension group were significantly higher than those in non-pulmonary hypertension group. After interventional or surgical treatment, the Tei index of right ventricle in patients with pulmonary hypertension was lower than that in the control group, and the Tei index of right ventricle in pulmonary hypertension group was lower than that in the control group, but still higher than that in the control group. Conclusion: Right ventricular function decline in patients with ASD, interventional and surgical treatment of patients with pulmonary hypertension in patients with right heart function improved significantly short-term efficacy; pulmonary hypertension patients with right heart function improved in the short term efficacy was not significant.