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[目的]研究子宫颈小细胞癌(SCCC)的治疗及预后。[方法]回顾性分析1998～2006年20例早期SCCC患者的临床病理资料。采用Kaplan-Meier进行单因素生存分析,以Log-Ranktest检验统计学差异。[结果]20例患者平均无瘤生存期37.1个月,平均总生存期45.0个月,3年生存率60%,5年生存率20%。肿瘤大小、深间质受侵、盆腔淋巴结阳性、脉管瘤栓是影响预后的高危因素。Ⅰ期与ⅡA期患者3年生存率差异具有显著性(P=0.023)。早期SCCC患者10例发生远处转移,远处转移率50%。[结论]FIGO分期是影响SCCC早期患者预后的独立因素。有复发转移高危因素的早期患者在手术及化疗的基础上联合放疗可以获得较好局控率。
[Objective] To study the treatment and prognosis of small cell carcinoma of the cervix (SCCC). [Methods] The clinical data of 20 early SCCC patients from 1998 to 2006 were retrospectively analyzed. One-way survival analysis was performed using Kaplan-Meier and statistical differences were tested using Log-Ranktest. [Results] Twenty patients had an average tumor-free survival of 37.1 months, an average total survival of 45.0 months, a 3-year survival rate of 60% and a 5-year survival rate of 20%. Tumor size, deep interstitial invasion, pelvic lymph node-positive, vascular tumor thrombus is a risk factor for prognosis. The difference of 3-year survival rate between stage Ⅰ and stage Ⅱ A patients was significant (P = 0.023). Ten cases of early SCCC distant metastasis, distant metastasis rate of 50%. [Conclusion] FIGO staging is an independent factor affecting the prognosis of patients with early SCCC. Early patients with risk factors for recurrence and metastasis based on surgery and chemotherapy combined with radiotherapy can get better control rate.