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目的评定高血压以及糖尿病患者早期肾损伤诊断工作中推行血生化指标联合尿生化指标测定方案的临床意义。方法 56例高血压患者作为A组、55例糖尿病患者作为B组,53例体检者作C组,测定所有入选对象的血生化指标以及尿生化指标,并进行比较。结果 A组患者血清β_2-微球蛋白(5.7±4.6)mg/L、血清胱抑素C(2.70±0.80)mg/L、尿谷氨酰转肽酶(120.5±26.3)U/L、尿微量白蛋白(46.1±20.6)mg/L、尿β_2-微球蛋白(9.40±8.80)μg/ml;B组患者上述指标分别为(6.9±5.3)mg/L、(2.30±0.60)mg/L、(114.5±35.2)U/L、(40.3±12.6)mg/L、(13.30±11.00)μg/ml,均高于C组体检者的(1.0±0.3)mg/L、(0.79±0.20)mg/L、(27.8±9.3)U/L、(9.1±2.6)mg/L、(0.14±0.03)μg/ml,差异有统计学意义(P<0.05)。结论糖尿病以及高血压早期肾损伤诊断工作中,选择测定血清β_2-微球蛋白、尿谷氨酰转肽酶、血清胱抑素C、尿微量白蛋白、尿β_2-微球蛋白等指标,可对患者肾脏组织受损状况进行早期诊断,有助于避免终末肾病出现。
Objective To evaluate the clinical significance of the combination of biochemical markers of blood biochemical markers in the diagnosis of hypertension and early renal injury in diabetic patients. Methods Fifty-six patients with hypertension were enrolled as group A, 55 as diabetes mellitus as group B and 53 as croup C. Blood biochemical and urinary biochemical parameters were measured and compared. Results Serum levels of β_2-microglobulin (5.7 ± 4.6) mg / L, serum cystatin C (2.70 ± 0.80) mg / L, urine glutamyl transpeptidase (120.5 ± 26.3) U / (46.1 ± 20.6) mg / L and urinary β_2-microglobulin (9.40 ± 8.80) μg / ml in group B. The above indexes in group B were (6.9 ± 5.3) mg / L and (2.30 ± 0.60) mg / L, (114.5 ± 35.2) U / L, (40.3 ± 12.6) mg / L and (13.30 ± 11.00) μg / ml respectively were significantly higher than those in group C (1.0 ± 0.3) mg / (27.8 ± 9.3) U / L, (9.1 ± 2.6) mg / L and (0.14 ± 0.03) μg / ml, respectively. There was significant difference between the two groups (P <0.05). Conclusion In the diagnosis of diabetes mellitus and hypertension with early renal damage, the indexes of serum β_2-microglobulin, urine glutamyl transpeptidase, serum cystatin C, urinary microalbuminuria and urinary β_2-microglobulin may be selected The early diagnosis of renal damage in patients with kidney disease can help prevent the emergence of.