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目的 观察A型肉毒毒素治疗偏侧面肌痉挛、眼肌痉挛、Meige综合征 (睑痉挛 -口颌肌张力障碍综合征 )及痉挛性斜颈的疗效。方法 用A型肉毒毒素对 6 4例肌张力障碍患者 (5 1例偏侧面肌痉挛、10例眼睑痉挛、1例Meige综合征、2例痉挛性斜颈 )行面部肌肉局部多点注射 ,分析其治疗效果。结果 5 1例偏侧面肌痉挛者 ,完全缓解 2 0例 (4 0 % ) ,明显缓解 30例 (5 9% ) ,1例无效 ;10例眼睑痉挛者 ,5例完全缓解 ,4例明显缓解 ,1例无效 ;1例Meige综合征部分缓解 ;2例痉挛性斜颈者 ,1例明显缓解 ,1例部分缓解 ;总有效率达 97%。起效时间数小时至 7天 ,缓解时间 3～ 7个月。局部副反应轻微、短暂 ,无全身反应及过敏反应。结论 A型肉毒毒素局部肌肉注射可有效控制局部肌张力过高 ,改善患者的异常面容和姿势。
Objective To observe the efficacy of botulinum toxin type A in the treatment of hemifacial spasm, oculomotor spasm, Meige syndrome (blepharospasm - maxillary dystonia syndrome) and spasmodic torticollis. Methods The botulinum toxin type A was given locally to the facial muscles of 64 cases of dystonia patients (51 cases of hemifacial spasm, 10 cases of blepharospasm, 1 case of Meige syndrome and 2 cases of spasmodic torticollis) Analyze its treatment effect. Results In 51 cases of hemifacial spasm, 20 cases (40%) were relieved completely, 30 cases (59%) were obviously relieved, and 1 case was ineffective. In 10 cases with blepharospasm, 5 cases were completely relieved and 4 cases were relieved , One case was ineffective; one case of Meige syndrome was partially relieved; two cases of spasmodic torticollis were relieved obviously in one case and partially relieved in one case; the total effective rate was 97%. The onset time of several hours to 7 days, relief time of 3 to 7 months. Local minor side effects, transient, no systemic reactions and allergic reactions. Conclusion Botulinum toxin type A intramuscular injection can effectively control the local hypertonia, improve the abnormal face and posture of patients.