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目的探讨内脏脂肪素基因启动子区-1535C/T基因多态性与宁夏回、汉族T2DM的相关性。方法用PCR-RFLP方法检测210例宁夏回、汉族T2DM患者(T2DM组)及207名健康对照者(NC组)内脏脂肪素启动子区-1535C/T位点多态性。结果两组间及两组内回、汉族内脏脂肪素基因启动子区-1535C/T基因多态性位点CC、CT、TT 3种基因型和等位基因频率差异均无统计学意义(P>0.05)。回族T2DM组TT基因型HDL-C低于CT、CC基因型(P=0.007),汉族T2DM组TT基因型TG较CC、CT基因型高(P=0.026)。结论内脏脂肪素基因启动子区-1535C/T位点存在多态性,两组间回、汉族差异无统计学意义;TT基因型可能与T2DM患者血脂异常有关。
Objective To investigate the association of the -1535C / T gene polymorphism in visceral adipose gene promoter region with T2DM in Hui people and Han nationality in Ningxia Hui Autonomous Region. Methods PCR-RFLP method was used to detect the polymorphism of -1535C / T in the visfatin promoter region in 210 cases of T2DM patients in Ningxia Hui and Han nationalities and in the control group of 207 healthy controls (NC group). Results There was no significant difference in the frequencies of CC, CT and TT genotypes between -1535C / T polymorphisms in the promoter region of the visfatin gene of Chinese Han and Han nationality > 0.05). The HDL-C of TT genotype in Hui T2DM group was lower than that of CT and CC genotype (P = 0.007). The TT genotype TG in Han T2DM group was higher than that of CC and CT genotype (P = 0.026). Conclusion The polymorphism of -1535C / T in the promoter region of visfatin gene is polymorphic. There is no significant difference between the two groups in the control group and the Han nationality. TT genotype may be related to dyslipidemia in T2DM patients.