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目的探讨一次性与多次根管充填治疗的适应症及疗效比较.方法随机选取并回顾性分析2010-01至2012-01于我院治疗慢性根尖周炎患者160例,研究组80例患者采用一次性根管充填治疗,对照组80例患者采用多次根管充填治疗.比较两组患者治疗后1周疼痛程度及1年内治疗效果.结果研究组Ⅰ级疼痛明显多于对照组,且前者理想镇痛率明显高于后者,存在统计学差异(p<0.05).研究组1年内治愈率明显高于对照组,两组差异存在统计学意义(p<0.05).结论在选好适应症的条件下,一次性根充,无论在术后疼痛还是治疗效果上都优于多次根管充填治疗,疗效明显,值得临床推广.“,”Objective: To discuss indication and clinical effect of permanent root canal filing and multiple root canal filing. Methods: Choosed 160 patients of chronic periapical periodontitis from Jan. 2010 to Jan. 2012. The study group were treated with permanent root canal filing with 80 cases, and controled group were treated with multiple root canal filing with 80 cases. Compared the degree of pain after 1 weeks and clinical effect after 1 year. Results: The I degree of pain in study group was significant more than controled group, but analgesic rate in study group was higher than controled group (p<0.05). The cure rate of study group after 1 year was higher than controled group (P<0.05). Conclusion: According to indication, permanent root canal filing has better clinical effect in cure rate or pain than multiple root canal filing to extend in clinical.