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[目的]探讨经皮穿刺组织间植入125I放射性粒子治疗中晚期肺癌疗效。[方法]对35例中晚期肺癌行CT引导下经皮穿刺组织间植入125I放射性粒子。肿瘤直径2~6cm,植入粒子数4~46粒,平均32粒,3例接受静脉化疗,7例接受深部热疗,2例行肝转移瘤冷极射频治疗。[结果]瘤体完全缓解20%(7/35),部分缓解62.8%(22/35),总有效率82.8%,1年生存率80%。并发症:术中咯血3例,气胸2例,粒子脱落移位1例,刺激性咳嗽1例,白细胞减少4例(其中2例同时行化疗)。[结论]CT引导下经皮穿刺组织间永久性植入125I粒子治疗中晚期肺癌可使瘤体明显缩小,并发症少,是一种创伤小,疗效肯定的治疗中晚期肺癌的方法。
[Objective] To investigate the therapeutic effect of 125I radioactive seeds implanted in percutaneous tissue between patients with advanced lung cancer. [Method] 125I radioactive particles were implanted into percutaneous tissue of 35 patients with advanced lung cancer under CT guidance. Tumor diameter of 2 ~ 6cm, the number of implanted particles 4 to 46, an average of 32 tablets, 3 patients received intravenous chemotherapy, 7 patients received deep hyperthermia, 2 patients with liver metastases cold radiofrequency treatment. [Results] Tumor completely relieved 20% (7/35), partially relieved 62.8% (22/35), total effective rate 82.8%, and 1-year survival rate 80%. Complications: 3 cases of hemoptysis, pneumothorax in 2 cases, particle shedding in 1 case, irritating cough in 1 case, leukopenia in 4 cases (including 2 cases of concurrent chemotherapy). [Conclusion] CT-guided permanent implantation of 125I particles in the percutaneous tissue between the two groups can significantly reduce the size of the tumor and reduce the number of complications. It is a less invasive and effective method for the treatment of advanced lung cancer.