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目的探讨采用尼莫地平治疗蛛网膜下腔出血后脑血管痉挛的临床效果及应用价值。方法回顾性分析56例蛛网膜下腔出血后脑血管痉挛患者的资料,按照随机、对照的原则分为观察组和对照组,各为28例。对照组患者给予脱水、降低颅内压、控制血压、止血、镇痛等常规的治疗,观察组在对照组的基础上,加用尼莫地平进行治疗。两组疗程均为15d,治疗结束后,观察和比较两组患者的临床治疗效果、治疗前后血压的比较。结果观察组临床治疗总有效率为100%,对照组为78.57%,差异有统计学意义;手术前两组患者的收缩压和舒张压比较差异无统计学意义;手术后两组患者的收缩压和舒张压均有所下降,差异有统计学意义,但观察组比对照组下降更为明显,差异有统计学意义。结论应用尼莫地平治疗蛛网膜下腔出血后脑血管痉挛效果较好,能够有效降低和控制患者的血压,改善预后。
Objective To investigate the clinical effect and application value of nimodipine in treating cerebral vasospasm after subarachnoid hemorrhage. Methods The data of 56 patients with cerebral vasospasm after subarachnoid hemorrhage were retrospectively analyzed. According to the principle of randomization and control, the patients were divided into observation group and control group, with 28 cases in each group. Patients in the control group were given conventional therapy such as dehydration, intracranial pressure reduction, blood pressure control, hemostasis and analgesia. The observation group was treated with nimodipine on the basis of the control group. Two groups of treatment were 15d, after treatment, the clinical efficacy of two groups were observed and compared, before and after treatment of blood pressure. Results The total effective rate of clinical observation was 100% in the observation group and 78.57% in the control group, the difference was statistically significant; there was no significant difference in systolic pressure and diastolic pressure between the two groups before operation; systolic pressure And diastolic blood pressure were decreased, the difference was statistically significant, but the observation group decreased more significantly than the control group, the difference was statistically significant. Conclusion Nimodipine is effective in treating cerebral vasospasm after subarachnoid hemorrhage, which can effectively reduce and control the blood pressure of patients and improve the prognosis.