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目的:探讨肺纤维化过程中细胞因子的调控网络。方法:应用荟萃分析筛选Wistar大鼠肺纤维化过程中肺组织的相关细胞因子。通过三次样条插值,采用线性微分方程模型进行网络调控的研究。结果:参与肺纤维化形成的相关细胞因子为IFN-γ,IL-10,IL-13,IL-18,IL-4,IL-5,IL-6,IL-8,IGF-1,MCP-1,PDGF,TGF-β1,TNF-α,MMP-2,MMP-9,EGF。构建的调控通路中重要的细胞因子节点为IFN-γ,IL-10,IL-13,IL-18,IL-6,IGF-1,PDGF,TGF-β1,TNF-α。结论:肺纤维化细胞因子网络由关键的细胞因子组成,非关键节点的细胞因子可能因致纤维化作用较小或仅参与炎症作用而未参加网络的调控。
Objective: To investigate the regulatory network of cytokines during pulmonary fibrosis. Methods: A meta-analysis was performed to screen for lung-related cytokines in Wistar rats during pulmonary fibrosis. Through cubic spline interpolation, the linear differential equation model is used to study the network regulation. Results: The related cytokines involved in the formation of pulmonary fibrosis were IFN-γ, IL-10, IL-13, IL-18, IL-4, IL-5, IL-6, IL-8, IGF- 1, PDGF, TGF-β1, TNF-α, MMP-2, MMP-9, EGF. The important cytokine nodes in the regulatory pathway were IFN-γ, IL-10, IL-13, IL-18, IL-6, IGF-1, PDGF, TGF-β1 and TNF-α. CONCLUSIONS: The pulmonary fibrosis cytokine network is composed of key cytokines. Non-key cytokines may not participate in the regulation of the network due to their small fibrosis effects or their involvement in inflammation.