异丙嗪是一种吩噻嗪类衍生物,本文对异丙嗪的两种栓剂与口服溶液和注射剂作单剂量给药的生物利用度比较。24名健康男性志愿者,年龄20～31岁,体重61～87kg,用交叉设计随机分成三组,每组8人。异丙嗪普通直肠栓剂、参比直肠栓剂和参比口服溶液分别 Promethazine is a phenothiazine derivative. In this paper, two suppositories of promethazine compared to the bioavailability of a single solution of an oral solution and an injection were compared. Twenty-four healthy male volunteers, aged 20-31 years and weighing 61-87 kg, were randomized into three groups of 8 with a crossover design. Promethazine general rectal suppository, reference rectal suppository and reference oral solution, respectively