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目的:研究多西他赛联合调强放疗治疗局部晚期非小细胞肺癌效果。方法:选择罗定市人民医院80例局部晚期非小细胞肺癌患者,按临床随机数表法随机分为对照组和观察组各40例。对照组行单独调强放疗治疗;观察组行多西他赛与调强放疗联合治疗。比较两组患者近期治疗效果、远期治疗效果及毒副反应发生率。结果:治疗后对照组患者近期治疗有效率(57.5%)低于观察组(80.0%),远期生存率(37.5%)低于观察组(62.5%),差异具有统计学意义(P<0.05);治疗后对照组患者骨髓抑制、放射性肺炎、放射性食管炎、放射性皮肤反应等毒副反应发生率与观察组比较,差异均无统计学意义(P>0.05)。结论:采用多西他赛联合调强放疗治疗局部晚期非小细胞肺癌,可提高近期疗效,延长患者生存期,减少毒副反应。
Objective: To study the effect of docetaxel combined with intensity modulated radiotherapy in the treatment of locally advanced non-small cell lung cancer. Methods: 80 patients with locally advanced non-small cell lung cancer in Luoding People’s Hospital were randomly divided into control group and observation group according to clinical random number table method. The control group was treated with IMRT alone; the observation group was treated with docetaxel and IMRT. The two groups of patients with short-term treatment effect, long-term treatment effect and the incidence of toxic reactions. Results: After treatment, the effective rate of treatment in the control group was lower than that in the observation group (57.5%), the long-term survival rate (37.5%) was lower than that in the observation group (62.5%), the difference was statistically significant (P <0.05 ). There was no significant difference in the incidence of bone marrow suppression, radiation pneumonitis, radiation esophagitis and radioactive skin reaction after treatment in the control group compared with the observation group (P> 0.05). Conclusion: Combination of docetaxel and intensity modulated radiotherapy for locally advanced non-small cell lung cancer can improve the short-term curative effect, prolong the survival of patients and reduce the side effects.