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目的探讨抗生素致肠道菌群失调性腹泻患儿血清C反应蛋白(CRP)的变化及其临床意义,并分析其临床特点。方法分析97例肠道菌群失调性腹泻患儿的临床资料,并采用酶联免疫法(ELISA)检测97例患儿和22名健康对照组儿童血清中CRP的变化。结果 97例肠道菌群失调性腹泻患儿均使用过抗菌药物,主要是第3代头孢菌素和2种或以上抗生素联合使用(占71.13%)。患儿感染的细菌以链球菌居多(占77.32%);肠道菌群失调性腹泻患儿血清中CRP的表达显著高于对照组(P<0.01);血清CRP的表达与患儿性别、年龄和抗生素使用情况无关(P>0.05)。结论小儿肠道菌群失调性腹泻主要危险因素是使用广谱抗菌药物,临床医生应重视早期病原学检查;同时,检测肠道菌群失调性腹泻患儿血清CRP的水平,对临床诊断和治疗具有重要意义。
Objective To investigate the changes and clinical significance of serum C-reactive protein (CRP) in children with intestinal flora dysbiosis caused by antibiotics and to analyze its clinical features. Methods The clinical data of 97 children with dysbacteriosis of intestinal flora were analyzed. The changes of CRP in serum of 97 children and 22 healthy controls were detected by enzyme-linked immunosorbent assay (ELISA). Results 97 cases of intestinal flora dysfunctional diarrhea in children were used antimicrobial drugs, mainly the third generation cephalosporins and two or more antibiotics combined (71.13%). The prevalence of streptococcus (77.32%) was significantly higher in children with bacterial infection than in controls (P <0.01). The expression of CRP in serum of children with intestinal dysbacteriosis diarrhea was significantly higher than that of control group And antibiotic use has nothing to do (P> 0.05). Conclusions The main risk factor of intestinal flora dysfunction diarrhea in children is the use of broad-spectrum antimicrobial drugs, clinicians should pay attention to early etiological examination; the same time, detection of intestinal flora in children with dysfunctional diarrhea serum CRP levels, clinical diagnosis and treatment It is of great significance.