论文部分内容阅读
目的:探讨加味参芪地黄汤含药血清对人系膜细胞分泌炎性介质的作用。方法:应用血清药理学方法,观察不同浓度加味参芪地黄汤含药血清对体外培养的人肾小球系膜细胞分泌IL-1β及IL-6水平的影响。结果:三种浓度含药血清均能在一定程度上对抗LPS诱导的IL-1β及IL-6蛋白质产量的增加,且这种对抗作用呈现出一定的剂量依赖性。结论:加味参芪地黄汤血清能干预活化的人肾小球系膜细胞分泌细胞因子,具有免疫调节作用。
Objective: To investigate the effect of serum containing Shenqi Dihuang Decoction on the secretion of inflammatory mediators from human mesangial cells. Methods: Serum pharmacological methods were used to observe the effects of different concentrations of Modified Shenqi Dihuang Decoction serum on the secretion of IL-1β and IL-6 from cultured human glomerular mesangial cells. Results: The three concentrations of drug-containing serum were able to resist LPS-induced increase of IL-1β and IL-6 protein production to a certain extent, and this antagonistic effect showed a dose-dependent manner. Conclusion: The serum of Shenqi Dihuang Decoction can intervene in the activated human glomerular mesangial cells to secrete cytokines and has immunoregulatory effect.