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目的探讨表观扩散系数(ADC)值对分析原发性肾小球肾炎肾脏功能的价值。方法对31例原发性肾小球肾炎患者和28例健康志愿者肾脏进行MR扩散加权成像(DWI)检查,依据原发性肾小球肾炎患者血清肌酐将病例组分为肌酐正常组(15例)和肌酐升高组(16例);测量选定部位的ADC值;比较3组间ADC值异同并分析ADC值与肌酐间的相关性。结果3组间肾脏ADC值均有统计学意义(P<0.05),原发性肾小球肾炎患者肾脏ADC值低于正常肾脏,肌酐升高组ADC值低于肌酐正常组。b值为1200s/mm2、1500s/mm2时肾脏ADC值与血清肌酐之间呈直线相关关系。结论ADC值可以评价原发性肾小球肾炎患者肾脏功能。
Objective To investigate the value of apparent diffusion coefficient (ADC) in the analysis of renal function in patients with primary glomerulonephritis. Methods 31 patients with primary glomerulonephritis and 28 healthy volunteers were examined by diffusion weighted imaging (DWI). According to serum creatinine in patients with primary glomerulonephritis, the cases were divided into normal creatinine group (15 Cases) and creatinine increased group (16 cases). The ADC value of selected sites was measured. The similarities and differences of ADC value between the three groups were compared and the correlation between ADC value and creatinine was analyzed. Results The ADC value of kidney in three groups was statistically significant (P <0.05). The ADC value of kidney in patients with primary glomerulonephritis was lower than that in normal kidneys. The ADC value in creatinine elevated group was lower than that in normal creatinine group. When the b value is 1200s / mm2, 1500s / mm2, there is a linear relationship between ADC value of the kidney and serum creatinine. Conclusion ADC value can evaluate renal function in patients with primary glomerulonephritis.