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目的:探讨HDL-P、HDL-C/P与早发冠心病发病风险相关性。方法:搜集2012年1月-2015年7月在我院心内住院患者458例,男性<55岁,女性<65岁,其中冠心病组216例,对照组242例,均行冠状动脉造影,搜集临床资料;采用核磁共振光谱技术检测HDL-P数量,将HDL-P数量分为3组,大颗粒、中颗粒和小颗粒;按HDL-C/P比值大小分为4组(HDL-C/P<41.0组,41.0-46.9组,47.0-52.9组和≥53.0组)以SPPS18.0统计软件进行统计分析。结果:(1)采用多元logistic回归分析,校正吸烟、饮酒、高血压、糖尿病史等危险因素后,大颗粒HDL-P与小颗粒HDL-P相比较,显著降低冠心病发病风险OR(95%CI)为0.253(0.104-0.611,P=0.002);(2)与HDL-C/P比值≥53组相比较,HDL-C/P<41组和41-46.9组均显著降低冠心病发病风险,OR(95%CI)分别为0.183(0.059-0.573),P≤0.01和0.295(0.099-0.883),P<0.05。结论:HDL-P、HDL-C/P可能是评估早发冠心病发病风险的重要指标。
Objective: To investigate the relationship between HDL-P, HDL-C / P and the risk of premature coronary heart disease. Methods: Forty-five in-patients hospitalized in our hospital from January 2012 to July 2015 were enrolled in this study. Male 55 years old and female 65 years old, including 216 cases of coronary heart disease and 242 cases of control group underwent coronary angiography, HDL-P was detected by nuclear magnetic resonance spectroscopy. The HDL-P levels were divided into three groups: large particles, medium particles and small particles. According to the HDL-C / P ratios, HDL-C /P<41.0group, 41.0-46.9group, 47.0-52.9group and≥53.0group) were analyzed by SPPS18.0 statistical software. Results: (1) Compared with small particles HDL-P, HDL-P could significantly reduce the risk of coronary heart disease OR (95%) by using multivariate logistic regression analysis after correcting risk factors such as smoking, drinking, hypertension and diabetes history, CI) was 0.253 (0.104-0.611, P = 0.002). (2) HDL-C / P <41 and 41-46.9 significantly reduced the risk of coronary heart disease compared with the HDL-C / P ratio of ≥53 , OR (95% CI) were 0.183 (0.059-0.573), P <0.01 and 0.295 (0.099-0.883) respectively, P <0.05. Conclusion: HDL-P and HDL-C / P may be important indexes for assessing the risk of premature coronary heart disease.