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近年来随着抗生素的广泛应用,耐药菌株也不断增加。我院自1996年1月至1998年12月共收治伤寒患者105例,其中28例为对喹诺类药物耐药患者,现将临床特点报告如下。 1 临床资料 1.1 一般资料:28例患者,男25例,女3例,年龄12～56岁,全部病例均符合《传染病学》伤寒的诊断标准。于入院前均经一种或2种抗生素治疗无效。26例患者经血培养或骨髓培养证实为伤寒,同时用改良K—B法作药敏试验。 1.2 临床症状及体征:热程:7天～10天4例(14.3％),11天～14天12例(42.9％),15天～21天10例(35.7％)。22天以上者2例(7.1％),其中最长1例达35天。热型:稽留热14例(50.0％),弛张热12例(42.9％),不规则热2例(7.1％)。
In recent years, with the widespread use of antibiotics, drug-resistant strains are also increasing. In our hospital from January 1996 to December 1998 a total of 105 cases of typhoid patients were admitted, of which 28 cases of quinol drugs resistant patients, the clinical features are reported as follows. 1 Clinical data 1.1 General information: 28 patients, 25 males and 3 females, aged 12 to 56 years old, all cases are in line with the “epidemiology” typhoid diagnostic criteria. One or two antibiotics were ineffective before admission. Twenty-six patients were confirmed as typhoid by blood culture or bone marrow culture, and drug susceptibility test by modified K-B method. 1.2 clinical symptoms and signs: heat: 7 days to 10 days in 4 cases (14.3%), 11 days to 14 days in 12 cases (42.9%), 15 days to 21 days in 10 cases (35.7%). There were 2 cases (7.1%) in more than 22 days, the longest in 1 case up to 35 days. Hot type: 14 cases of missed heat (50.0%), remission fever in 12 cases (42.9%), irregular fever in 2 cases (7.1%).