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目的:比较胰岛素泵皮下注射胰岛素(CSII)与每天多次皮下注射胰岛素(MSII)对糖尿病合并脑出血患者血糖控制及神经功能缺损改善的差异。方法:80例糖尿病合并脑出血患者随机分为2组各40例,均接受急性脑出血常规处理,MSII组同时行MSII治疗,CSII组同时行CSII治疗,比较2组血糖控制情况,并与治疗前与治疗2周后使用美国国立卫生研究脑卒中量表(NIHSS)评定2组神经功能。结果:与MSII组比较,CSII组血糖控制达到靶血糖值的时间缩短,胰岛素用量及低血糖的发生次数减少(P<0.05);2组治疗后NIHSS评分和死亡率均明显降低(P<0.05),而以CSII组更显著(P<0.01)。结论:与MSII比较,CSII更适用于治疗糖尿病合并急性脑出血,能更有效地控制血糖,改善神经功能。
OBJECTIVE: To compare the differences in blood glucose control and neurological deficits between diabetic patients with cerebral hemorrhage and insulin subcutaneous injection of insulin (CSII) and multiple daily subcutaneous injections of insulin (MSII). Methods: Eighty diabetes mellitus patients with cerebral hemorrhage were randomly divided into two groups (n = 40). All of them were given routine treatment of acute intracerebral hemorrhage. The patients in MSII group were treated with MSII at the same time. The patients in CSII group were treated with CSII at the same time. Two weeks before and after treatment, two sets of neurological functions were assessed using the National Institutes of Health Stroke Scale (NIHSS). Results: Compared with the MSII group, the CSII group had shorter blood glucose control time, less insulin and hypoglycemia (P <0.05), and NIHSS score and mortality in the two groups were significantly decreased (P <0.05 ), But more significant in CSII group (P <0.01). Conclusion: Compared with MSII, CSII is more suitable for the treatment of diabetic patients with acute cerebral hemorrhage, which can control blood sugar more effectively and improve neurological function.