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血清胰岛素样生长因子（ＩＧＦｓ）、胰岛素样生长因子结合蛋白（ＩＧＦＢＰｓ）代谢紊乱是肾病综合征（ＮＳ）患儿生长障碍的发生机制之一。ＩＧＦＢＰｓ的异常分布，促使血清ＩＧＦｓ随１５０ＫＤ大分子复合物向易于从肾小球滤过的４０～５０ＫＤ小分子复合物迁移，从而进一步加重血清ＩＧＦｓ、ＩＧＦＢＰｓ的紊乱，加剧ＮＳ患儿生长障碍的发生。
Serum insulin-like growth factor (IGFs), insulin-like growth factor binding protein (IGFBPs) metabolic disorder is one of the mechanisms of growth disorders in children with nephrotic syndrome (NS). Abnormal distribution of IGFBPs, promote serum IGFs with 150KD macromolecular complexes easily migrate from the glomerular filtration 40-50KD small molecule complexes, thereby further aggravating serum IGFs, IGF BPs disorders, aggravating growth disorders in children with NS happened.