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分别选择某农药厂甲萘威生产女工67名为暴露组、厂行政办公区女性工作人员47名为对照组。对环境空气中甲萘威及其相关气体如异氰酸甲酯(MIC)、氨气及总酚进行持续3d的监测,同时选择暴露区及对照区各3人进行个体采样和皮肤污染量测定;运用回顾性队列研究的方法对其月经和妊娠结局进行评价。测定其血清中的卵泡刺激素(FSH)、黄体生成素(LH)、孕酮(P)、催乳素(PRL)和雌二醇(E2)水平。结果显示暴露组空气中甲萘威、总酚浓度明显高于对照组(P<0.01),个体采样及皮肤污染量结果均显示暴露组甲萘威浓度显著高于对照组(P<0.01);暴露组自然流产发生率显著高于对照组(P<0.05)。提示甲萘威农药生产职业暴露可能对女工的妊娠结局有一定的影响。
Sixty-seven female workers in a pesticide plant carbaryl were selected as the exposure group, and 47 female workers in the administrative office area were selected as the control group. Carbendazim and its related gases such as methyl isocyanate (MIC), ammonia and total phenol in ambient air were monitored for 3 days. Three individuals in the exposed area and in the control area were selected for individual sampling and determination of skin contamination ; The use of retrospective cohort study of menstrual and pregnancy outcomes were evaluated. Serum levels of FSH, LH, PR, PRL and E2 were measured. The results showed that the concentration of carbaryl in the exposed group was significantly higher than that in the control group (P <0.01). The results of individual sampling and skin contamination showed that the concentration of carbaryl in the exposed group was significantly higher than that in the control group (P <0.01). The incidence of spontaneous abortion in the exposed group was significantly higher than that in the control group (P <0.05). It is suggested that occupational exposure to carbaryl pesticide production may have a certain impact on the pregnancy outcome of female workers.