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为了评价甲氰咪胍与抗酸剂预防应激性溃疡的效果,作者对监护病房内44例具有应激性溃疡危险因素(如休克、脓毒病、多发性外伤,以及呼吸,肾,肝衰竭等)的重危病人行随机分组(不包括近期头颈部手术,入院前胃肠道出血、胃食道手术及72小时内服用阿斯匹林或近期心肌梗塞的患者),分别给予甲氰咪胍或抗酸剂Mglanta Ⅱ治疗.给所有病人安置鼻胃管以测定pH.甲氰咪胍组经前臂静脉给药,初期剂量300mg/6h,最大剂量400mg/4h;抗酸剂组经鼻胃管滴入MglantaⅡ,初期剂量30ml/h,最大剂量90ml/h;最小剂量须维持胃液pH≥4,给药间歇期及剂量根据pH调整.受试患者每小时测定并记录pH值,直接观察鼻胃管抽吸液或作潜血试验.以往胃镜研究表明大多数应激性溃疡
In order to evaluate the effect of cimetidine and antacid in the prevention of stress ulcer, the authors analyzed 44 patients with stress ulcer risk factors (such as shock, sepsis, multiple trauma, and respiratory, kidney, liver Failure, etc.) were randomly assigned to randomization (excluding recent head and neck surgery, pre-admission gastrointestinal bleeding, gastroesophageal surgery and patients taking aspirin or a recent myocardial infarction within 72 hours) The patients were given nasogastric tube to determine the pH value.Amethymidine group was given intravenously by the forearm, the initial dose of 300mg / 6h, the maximum dose of 400mg / 4h; antacid group nasal The gastric tube was instilled into Mglanta Ⅱ, the initial dose was 30ml / h, the maximum dose was 90ml / h, the minimum dose was to maintain the gastric juice pH≥4, and the dosage interval was adjusted according to the pH value. Nasal tube aspiration fluid or occult blood test. Previous gastroscopic studies have shown that most of the stress ulcer