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目的 探讨维生素E(VitE)水平在肝细胞癌变过程中的改变与作用机制。方法 用2FAA制备大鼠肝癌动物模型,在肝细胞癌变过程中观察其肝组织学、肝总RNA水平及血清VitE含量的动态改变,并对不同肝病患者血清中VitE的浓度进行了分析。结果 在肝细胞癌变过程中,鼠血清中VitE含量呈逐渐降低,而鼠肝总RNA水平逐渐增加趋势;在急性肝炎、慢性肝炎、肝硬变和肝癌患者血清中VitE含量均显著低于正常对照(P<0.05),而肝癌组血清VitE水平显著低于急性肝炎、慢性肝炎和肝硬变组(P<0.001)。结论 肝脏癌变过程中VitE量显著减少而总RNA水平显著升高,这种改变可能与体内氧化/抗氧化系统失衡有关。
Objective To investigate the change and mechanism of vitamin E in the course of carcinogenesis of hepatocellular carcinoma. Methods Animal models of rat liver cancer were established by 2FAA. The changes of liver histology, total RNA and serum VitE levels in hepatocellular carcinogenesis were observed. The serum levels of VitE in patients with different liver diseases were also analyzed. Results In the process of hepatocellular carcinogenesis, the content of VitE in rat serum decreased gradually and the level of total RNA in rat liver increased gradually. The content of VitE in serum of patients with acute hepatitis, chronic hepatitis, cirrhosis and liver cancer was significantly lower than that of normal control (P <0.05), while the level of serum VitE in hepatocellular carcinoma was significantly lower than that in acute hepatitis, chronic hepatitis and cirrhosis group (P <0.001). Conclusions The amount of VitE decreased significantly and the total RNA level increased significantly during carcinogenesis of liver, which may be related to the imbalance of oxidation / anti-oxidation system in vivo.