论文部分内容阅读
目的 :探讨表皮生长因子 (EGF)及表皮生长因子受体 (EGFR)表达和胃癌预后的关系。方法 :对 6 2例病人的胃癌标本进行EGF及EGFR的免疫组化链霉亲和素 生物素酶标法 (LSAB)检测。结果 :EGF表达阳性者的胃癌淋巴结转移率为 77 3% ,其 5年生存率为 18 2 % ,EGFR表达阳性者的淋巴结转移可能性为 82 1% ,5年生存率为14 3%。结论 :胃癌EGF或EGFR表达阳性者均易出现淋巴结转移 ,且 5年生存率均低 ,二者可作为评估胃癌预后指标
Objective : To investigate the relationship between epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) expression and prognosis of gastric cancer. Methods: EGF and EGFR immunohistochemical streptavidin-biotinylated enzyme-linked immunosorbent assay (LSAB) were used to detect gastric cancer in 62 patients. Results: The lymph node metastasis rate in patients with positive EGF expression was 77 3%. The 5-year survival rate was 18 2%. The positive rate of lymph node metastasis was 82 1% in patients with positive EGFR expression. The 5-year survival rate was 14 3%. Conclusion: Lymph node metastasis is easy to occur in patients with gastric cancer with positive expression of EGF or EGFR, and the 5-year survival rate is low. Both can be used as prognostic indicators for gastric cancer.