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目的:了解广东瑶族无偿献血者血液传播肝炎病毒及人细小病毒B19感染现状,探讨HBV、HCV、HDV、HGV、TTV及HPV B19感染相关性。方法:采用ELISA法分别检测血液中HBsAg、抗-HCV、抗-HDV-IgG、抗-HGV-IgG、抗-TTV-IgG及HPV B19IgG。结果:376例无偿献血者血液标本中,HBsAg、抗-HCV、抗-HDVIgG、抗-HGV-IgG、抗-TTV-IgG及HPV B19IgG阳性检出率分别为1.86%、0.80%、0.53%、8.78%、46.81%和29.26%,男女性别之间阳性率差异无统计学意义。检出各种病毒标志物238例,占63.30%,单一病毒感染160例,占42.55%,重叠感染78例,占20.75%。单一病毒感染以TTV为多,达44.54%,重叠感染以TTV+HPV B19为主,达到18.91%,二重感染67例(28.15%),多重感染11例(4.62%)。结论:广东瑶族无偿献血者存在不同程度的HBV、HCV、HDV、HGV、TTV及HPV B19感染和重叠感染。HDV、HGV、TTV及HPV B19尚未在无偿献血人群中开展筛查工作,存在输血传播的风险。
Objective: To understand the status of blood-borne hepatitis B virus and human parvovirus B19 infection in unpaid blood donors in Guangdong and to investigate the correlation between HBV, HCV, HDV, HGV, TTV and HPV B19 infection. Methods: HBsAg, anti-HCV, anti-HDV-IgG, anti-HGV-IgG, anti-TTV-IgG and HPV B19 IgG in blood were detected by ELISA. Results: The positive rates of HBsAg, anti-HCV, anti-HDVIgG, anti-HGV-IgG, anti-TTV-IgG and HPV B19 IgG in 376 blood donors were 1.86%, 0.80% and 0.53% 8.78%, 46.81% and 29.26% respectively. There was no significant difference in the positive rate between male and female. A total of 238 cases of various virus markers were detected, accounting for 63.30%. A single virus infection was found in 160 cases (42.55%) and overlap infection in 78 cases (20.75%). The single virus infection accounted for 44.54% of the patients with TTV infection. The prevalence of infection was 18.91% in TTV + HPV B19, 67 (28.15%) in double infection and 11 (4.62%) in multiple infection. Conclusion: There are varying degrees of HBV, HCV, HDV, HGV, TTV and HPV B19 infection and overlap infection in the non-reimbursed blood donors of Yao ethnic group in Guangdong province. HDV, HGV, TTV and HPV B19 have not yet been screened in the blood-donated population, with the risk of blood transfusion transmitted.