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目的 调查西安地区不同类型肝炎患者输血传播病毒 (TTV)感染状况并探讨其临床意义 .方法 在病毒 ORF1区设计内 /外两对引物 ,采取 nested- PCR方法 ,检测病毒性肝炎患者 147例和非病毒性肝炎患者 12 8例血清中 TTVDNA.结果 在肝炎组中 ,TTV基因检测阳性率分别为非甲-非戊型肝炎 6 0 .0 % (9/ 15 ) ,庚型肝炎 5 0 .0 % (6 / 12 ) ,乙型肝炎 2 6 .2 % (2 1/ 80 ) ,丙型肝炎 11.1% (3/ 2 7) ,甲型肝炎 0 (0 /6 ) ,甲型肝炎合并丙型肝炎 0 (0 / 2 ) ,乙型肝炎合并丙型肝炎为 6 0 .0 % (3/ 5 ) ,非肝炎对照组 2 .3% (3/ 12 8) .结论 西安地区不同类型肝炎患者中 ,除甲肝和甲肝合并丙肝外均有 TTV重叠感染 ,其中以非甲 -非戊型肝炎和庚型肝炎最高 .从以上结果推断 TTV可能有致病性
Objective To investigate the infection status of transfusion transmitted virus (TTV) in patients with different types of hepatitis in Xi’an and to explore its clinical significance.Methods Two pairs of primers were designed in / ORF1 region of neovasculature to detect 147 cases of viral hepatitis The results showed that the positive rates of TTV gene in hepatitis group were 60.0% (9/15) for non-A-HEV and 50.0% (6/12), hepatitis B (62.2%), hepatitis C 11.1% (3/27), hepatitis A 0 (0 6), hepatitis A with hepatitis C (0/2), hepatitis C with hepatitis C 60.0% (3/5), non-hepatitis control group 2.3% (3/128) .Conclusion In the patients with different types of hepatitis in Xi’an, In addition to hepatitis A and hepatitis C with hepatitis C both have overlapping TTV infection, of which non-non-hepatitis E and hepatitis G are the highest from the above results concluded that TTV may have pathogenic