论文部分内容阅读
目的:探讨慢性阻塞性肺疾病患者、健康吸烟者及非吸烟者呼出气冷凝液中白细胞介素-6水平的差异及临床意义。方法:选择缓解期慢性阻塞性肺疾病患者30例及对照组38例(健康吸烟者20例、非吸烟者18例)为研究对象,收集呼出气冷凝液,以ELISA法测定白细胞介素-6水平,并进行比较。结果:缓解期慢性阻塞性肺疾病组呼出气冷凝液中白细胞介素-6水平高于对照组非吸烟者(P<0.01),与对照组吸烟者比较差异无统计学意义(P>0.05);对照组吸烟者与非吸烟者比较差异有统计意义(P<0.05)。结论:缓解期慢性阻塞性肺疾病患者存在持续气道炎症及氧化应激,健康吸烟者气道炎症程度增加。
Objective: To investigate the difference and clinical significance of interleukin-6 in patients with chronic obstructive pulmonary disease (COPD), healthy smokers and non-smokers with exhaled breath condensate. Methods: Thirty patients with chronic obstructive pulmonary disease (COPD) and 38 control subjects (20 healthy smokers and 18 non-smokers) were selected as study objects. Exhaled air condensate was collected and the levels of interleukin-6 Level and compare. Results: The level of IL - 6 in exhaled breath condensate of COPD patients in remission group was higher than that in control group (P <0.01), there was no significant difference between smokers and control group (P> 0.05) There was significant difference between control group smoker and non-smoker (P <0.05). CONCLUSION: Continuous airway inflammation and oxidative stress are present in patients with COPD in remission, and airway inflammation is increased in healthy smokers.