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目的观察在新生儿肺透明膜病治疗中应用固尔苏与鼻塞式持续气道正压通气联合治疗的临床效果。方法选取福建省南平市妇幼保健院2014年12月-2016年12月收治的新生儿肺透明膜病患儿62例,依据计算机表法将患者随机为试验组及参照组各31例,将采取头罩吸氧患儿作为参照组,将实行固尔苏与鼻塞式持续气道正压通气联合治疗患者作为试验组,观察2组患儿的治疗效果及治疗前后的血气分析指标。结果试验组患儿治疗总有效率为96.77%明显高于参照组的74.19%,差异有统计学意义(χ2=6.3690,P<0.05)。2组患儿治疗前p H、Pa CO2、Pa O2等指标差异无统计学意义(P>0.05)。治疗后试验组患儿p H、Pa O2均高于治疗前及对照组,Pa CO2水平低于治疗前及对照组,差异均有统计学意义(P<0.05)。结论将固尔苏与鼻塞式持续气道正压通气联合治疗应用于新生儿肺透明膜病中疗效显著,可提升治愈率,降低使用机械通气的概率,提高治疗整体安全性。
Objective To observe the clinical effect of the combination of Gulsu and nasal continuous positive airway pressure ventilation in the treatment of neonatal hyaline membrane disease. Methods Sixty-two neonates with hyaline membrane disease were selected from Nanfang MCH hospital from December 2014 to December 2016. According to the computer table method, the patients were randomly divided into the experimental group and the reference group of 31 cases each As a reference group, patients with hood oxygen inhalation were treated with Gul-Su and nasal continuous positive airway pressure ventilation as experimental group. The therapeutic effect and blood gas analysis index before and after treatment in both groups were observed. Results The total effective rate of treatment group was 96.77%, which was significantly higher than 74.19% of the reference group (χ2 = 6.3690, P <0.05). There was no significant difference in p H, PaCO 2, Pa O 2 before treatment between two groups (P> 0.05). After treatment, the levels of p H and Pa O2 in the experimental group were higher than those before treatment and in the control group, and the PaCO 2 level in the experimental group was lower than that before treatment and in the control group (P <0.05). Conclusion The combination of Gul-Su and nasal continuous positive airway pressure ventilation in the treatment of neonatal hyaline membrane disease has significant curative effect, which can improve the cure rate, reduce the probability of using mechanical ventilation and improve the overall safety of treatment.