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目的研究冠心病患者外周血清中脂蛋白(1)、高敏C反应蛋白和D-二聚体的变化,进一步探讨其在冠心病中的临床应用价值。方法随机抽取我院2016年1月至2017年1月在本院就诊的冠心病患者150例,其中,男110例,女40例,平均年龄(53±10.7)岁。150例患者中,急性心肌梗死48例,不稳定型心绞痛55例,稳定型心绞痛47例;并选择同期在本院健康体检人员120例作为健康对照组,分别检测脂蛋白(a)、高敏C反应蛋白和D-二聚体的含量。结果冠心病患者血中脂蛋白(a)、高敏C反应蛋白均明显高于对照组,差异有统计学意义(P<0.05)。稳定型心绞痛患者血清中超敏C反应蛋白含量比健康人明显增高(P<0.05),而D-二聚体的增高不明显(P=0.07)。结论脂蛋白(a)、高敏C反应蛋白和D-二聚体含量变化与冠心病有密切相关,是冠心病发生的重要危险因素,同时检测3项指标均能较好地反映冠心病患者的病情,对冠心病的早期诊断、治疗及疗效观察具有重要的临床应用价值。
Objective To study the changes of lipoprotein (1), high-sensitivity C-reactive protein and D-dimer in peripheral blood serum of patients with coronary heart disease and further explore its clinical value in coronary heart disease. Methods A total of 150 patients with CHD who were admitted to our hospital from January 2016 to January 2017 were randomly selected, including 110 males and 40 females, with an average age of (53 ± 10.7) years. Among the 150 patients, there were 48 cases of acute myocardial infarction, 55 cases of unstable angina pectoris and 47 cases of stable angina pectoris. In the same period, 120 healthy people in our hospital were selected as healthy control group, and the levels of lipoprotein (a) Reactive protein and D-dimer content. Results Serum lipoprotein (a) and high-sensitivity C-reactive protein in patients with coronary heart disease were significantly higher than those in the control group (P <0.05). Serum levels of hypersensitive C-reactive protein in patients with stable angina were significantly higher than those in healthy subjects (P <0.05), while D-dimer did not increase significantly (P = 0.07). Conclusion The changes of lipoprotein (a), high-sensitivity C-reactive protein and D-dimer are closely related to coronary heart disease, which are important risk factors of coronary heart disease. All the three indexes can reflect the changes of coronary heart disease Disease, coronary heart disease early diagnosis, treatment and efficacy of observation has important clinical value.