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目的探讨错配修复基因hMSH2在宫颈癌组织中的表达及意义。方法应用免疫组织化学方法检测hMSH2蛋白在34例正常宫颈及46例宫颈癌组织中的表达。结果hMSH2在正常宫颈和宫颈癌组织中阳性表率分别为26.47%和80.43%,差异有统计学意义。hMSH2的表达与宫颈癌的临床分期、病理分级、淋巴转移与无关。结论hMSH2可作为宫颈癌筛查及早期诊断的指标之一。
Objective To investigate the expression of mismatch repair gene hMSH2 in cervical cancer and its significance. Methods Immunohistochemistry was used to detect the expression of hMSH2 protein in 34 normal cervical tissues and 46 cervical cancer tissues. Results The positive rates of hMSH2 in normal cervical and cervical cancer tissues were 26.47% and 80.43%, respectively, with statistical significance. The expression of hMSH2 is related to the clinical stage, pathological grade, lymphatic metastasis and cervical cancer. Conclusion hMSH2 can be used as an indicator of cervical cancer screening and early diagnosis.