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目的:观察辛伐他汀治疗老年高血压伴高脂血症患者的临床疗效。方法:将84例确诊的老年高血压伴高脂血症患者随机分为两组,各42例;两组均采用常规降压治疗方案,观察组在此基础上加服辛伐他汀片20mg,每日晚间顿服,12周为1个疗程;比较两组患者治疗前后动态血压及降压平滑指数的变化情况。结果:疗程结束时,观察组收缩压较治疗前明显降低(P<0.01),且较对照组亦明显降低(P<0.05);观察组降压平滑指数较对照组明显增高(P<0.01)。结论:老年高血压伴高脂血症患者在予常规降压药物治疗的基础上,予调脂药辛伐他汀可产生协同降压作用,较单纯降压治疗能够更明显地提高降压平滑性。
Objective: To observe the clinical efficacy of simvastatin in the treatment of elderly patients with hypertension and hyperlipidemia. Methods: Eighty-four elderly hypertensive patients with hyperlipidemia were randomly divided into two groups, 42 cases in each group. Conventional antihypertensive treatment was used in both groups. In the observation group, 20 mg of simvastatin tablets, Day night evening service, 12 weeks for a course of treatment; before and after treatment in patients with ambulatory blood pressure and blood pressure-smoothing index changes. Results: At the end of treatment, the systolic blood pressure in the observation group was significantly lower than that in the control group (P <0.01), and also significantly lower than that in the control group (P <0.05). The antihypertensive index of the observation group was significantly higher than that of the control group (P <0.01) . Conclusion: The elderly patients with hyperlipidemia and hyperlipidemia on the basis of conventional antihypertensive drug treatment, the prostaglandin-lowering statin can produce a synergistic antihypertensive effect, compared with the simple antihypertensive treatment can be more significant to improve antihypertensive smoothness .