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目的观察不完全系统性红斑狼疮(ILE)患者的临床随访研究结果,探索其病情进展预测因素。方法对ILE患者定期随访,记录其临床资料及实验室检查结果,随访结束时分析病情进展预测因素。结果共有19例ILE患者入选本项研究。在3年的随访研究中,有11例ILE患者发展为SLE。危险因素分析显示颧部红斑、光过敏、抗dsDNA抗体阳性与SLE进展相关。结论在本次随访研究中,虽有58%的ILE患者最后进展为SLE,但所有患者的SLEDAI分值都较低,提示ILE为狼疮的一种比较轻的亚型。颧部红斑、光过敏及抗ds-DNA抗体阳性预示这些患者可能发展为SLE.
Objective To observe the clinical follow-up results of patients with incomplete systemic lupus erythematosus (ILE) and explore the predictors of their progression. Methods Regular follow-up of ILE patients was performed. The clinical data and laboratory findings were recorded. Predictors of disease progression were analyzed at the end of follow-up. Results A total of 19 patients with ILE were enrolled in this study. Eleven patients with ILE developed SLE in a 3-year follow-up study. Risk factor analysis showed erythema of the zygomatic majus, photodamage, anti-dsDNA antibody positive correlated with the progress of SLE. Conclusions Although 58% of ILE patients eventually progressed to SLE in this follow-up study, all patients had low SLEDAI scores, suggesting that ILE is a relatively mild subtype of lupus. Zygomatic erythema, photosensitivity and anti-ds-DNA antibody positive predicts that these patients may develop SLE.