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目的为了了解P16 蛋白在骨肉瘤中的表达及其与患者临床资料间的关系 ,研究P16 蛋白与骨肉瘤发生、发展间的关系。方法采用免疫组织化学方法检测18例正常骨组织 ,52例骨肉瘤标本 (其中27例有化疗前后配对标本 ) ,并作统计学对照处理。结果P16蛋白在骨肉瘤标本中的表达显著高于正常骨组织 (P<0.01) ,与骨肉瘤转移、化疗、病理类型及生存率无关 ,而与肿瘤的直径大小有关。结论P16蛋白表达的改变可能与骨肉瘤的发生、发展有关。
Objective To understand the expression of P16 protein in osteosarcoma and its relationship with clinical data of patients to study the relationship between the P16 protein and the occurrence and development of osteosarcoma. Methods 18 cases of normal bone tissue and 52 cases of osteosarcoma were detected by immunohistochemical method (including 27 cases with paired specimens before and after chemotherapy), and were treated with statistical control. Results The expression of P16 protein in osteosarcoma specimens was significantly higher than that in normal bone tissues (P <0.01), which was not related to the metastasis, chemotherapy, pathological type and survival rate of osteosarcoma, but was related to the diameter of tumor. Conclusion The change of P16 protein expression may be related to the occurrence and development of osteosarcoma.