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透皮给药(TDD)系统可达到全身治疗的目的,且无静脉给药的潜在危险。TDD系统按工艺特点可分为膜控释型、粘性聚合物中药物分散型、非粘性聚合物中药物分散型和微小贮库控制溶出型。但这些TDD系统适用于亲脂性的小分子药物,如硝酸甘油。由于TDD系统中的药物分子需通过被动扩散转运,限制了大分子亲水性肽及蛋白质类药物制成TDD制剂。肽及蛋白类药物是由α-氨基酸组成的肽链,各有其特殊排列与分子构型,表现不同的治疗作用。许多新的肽类制剂已批量生产,有的生物活性极强。日剂量只需几微克,已
Transdermal drug delivery (TDD) systems achieve the goal of systemic therapy without the potential risk of intravenous administration. TDD system according to process characteristics can be divided into controlled-release film, viscous polymer dispersion drugs, non-sticky polymer dispersion drug-controlled and tiny reservoir control dissolution. However, these TDD systems are suitable for lipophilic small molecule drugs such as nitroglycerin. Because of the need for passive diffusion of drug molecules in TDD systems, TDD formulations are limited to macromolecule hydrophilic peptides and proteinaceous drugs. Peptides and protein drugs are composed of α-amino acid peptide chain, each with its special arrangement and molecular configuration, showing different therapeutic effects. Many new peptide preparations have been mass-produced, and some are highly bioactive. Daily dose only a few micrograms, have