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目的:探讨血清中甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原125(CA125)单独以及联合检测对于原发性肝癌的早期诊断临床价值。方法:选择2012年1月~2016年6月在我院检验科确诊的120例原发性肝癌患者作为观察组,并以80例健康志愿者作为对照组,检测和比较两组的AFP、CEA和CA125水平,分析血清AFP、CEA、CA125单项及联合检测检出原发性肝癌的阳性率和约登指数。结果:观察组血清AFP(319.53±35.78 ng/mL)、CEA(81.4±27.8 ng/mL)、CA125(20.67±4.61 ng/mL)水平均明显高于健康对照组(P<0.05)。血清AFP、CEA、CA125在单独检测时诊断原发性肝癌的敏感性分别为65%(78/120)、75%(90/120)和60%(72/120),而三者的联合检测能够使检测的敏感性达到92%(112/120),显著高于单独检测时的敏感度(P<0.05)。血清AFP、CEA、CA125单项检测约登指数均显著低于联合检测(P<0.05)。结论:相较于血清AFP、CEA、CA125的单独检测,三者联合检测可明显提高原发性肝癌的检出率。
Objective: To investigate the clinical value of serum alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125) alone and in combination for early diagnosis of primary liver cancer. Methods: One hundred and twenty patients with primary hepatocellular carcinoma diagnosed in our laboratory from January 2012 to June 2016 were selected as the observation group and 80 healthy volunteers as the control group. The AFP, CEA And CA125 levels were analyzed. The positive rate and Youden index of primary liver cancer detected by single and combined detection of serum AFP, CEA and CA125 were analyzed. Results: The levels of serum AFP (319.53 ± 35.78 ng / mL), CEA (81.4 ± 27.8 ng / mL) and CA125 (20.67 ± 4.61 ng / mL) in the observation group were significantly higher than those in the healthy control group (P <0.05). The sensitivity of serum AFP, CEA and CA125 in the diagnosis of primary hepatocellular carcinoma when tested alone was 65% (78/120), 75% (90/120) and 60% (72/120), respectively. The combined detection of the three The sensitivity of the assay was 92% (112/120), which was significantly higher than that of the test alone (P <0.05). The Yden index of serum AFP, CEA, CA125 single detection were significantly lower than the combined detection (P <0.05). Conclusion: Compared with the serum AFP, CEA, CA125 alone test, the three combined detection can significantly improve the detection rate of primary liver cancer.