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本文采用48只雄性新西兰纯系家兔,分成4组,观察中药有效成分8501在实验性动脉粥样硬化形成过程中降低胆固醇和预防斑块形成的作用。结果表明,8501可以明显降低血清胆固醇、主动脉组织胆固醇酯(CE)及总胆固醇(TC)含量,对抗高脂饲料,降低血清α-脂蛋白比例的作用,并可使主动脉粥样硬化斑块面积明显小于高脂组。阿斯匹林虽有降低血清胆固醇含量、轻度升高α-脂蛋白比例的作用,但主动脉组织TC、CE含量及斑块形成面积与高脂组无明显差异。
In this study, 48 male New Zealand purebred rabbits were divided into four groups to observe the effect of traditional Chinese medicine active ingredient 8501 on reducing cholesterol and preventing plaque formation during experimental atherosclerosis. The results showed that 8501 can significantly reduce serum cholesterol, aortic tissue cholesterol ester (CE) and total cholesterol (TC), against high-fat diet, reduce the role of serum α-lipoprotein ratio, and can make the Atherosclerosis plaque Block area was significantly less than high-fat group. Although aspirin lowered the level of serum cholesterol and slightly increased the ratio of α-lipoprotein, there was no significant difference in TC, CE content and plaque formation area between aorta and hyperlipidemia group.