论文部分内容阅读
目的 :探讨ｐ1 6基因甲基化与儿童急性白血病 (ＡＬ)的发生、发展、预后的关系。方法 :用酶切加ＰＣＲ技术研究 33例初治儿童ＡＬ ,1 5例复发儿童ＡＬ及 30例对照组ｐ1 6基因甲基化情况 ,并观察ｐ1 6基因甲基化与化疗结果的关系。结果 :33例初治ＡＬ有 3例、1 5例复发ＡＬ有 6?
Objective: To investigate the relationship between the methylation of p16 gene and the occurrence, development and prognosis of childhood acute leukemia (AL). Methods: The methylation status of p16 gene in 33 children with AL, 15 children with recurrent AL and 30 controls was studied by enzyme digestion and PCR. The relationship between p16 methylation and chemotherapy was also observed. Results: 33 cases of initial treatment of AL in 3 cases, 15 cases of recurrent AL 6?