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目的:观察急性结膜炎炎症急性期和炎症缓解后的血浆炎性细胞因子水平变化。方法:应用放射免疫分析法和超敏免疫分析测定了127例急性结膜炎患者治疗前后血浆白介素(IL)-1β、IL-6、IL-8、肿瘤坏死因子-α(TNF-α)和超敏-C反应蛋白(hs-CRP)水平,并与正常对照组进行比较,行相关性分析。结果:127例急性结膜炎患者治疗前后血浆IL-1β、IL-6、IL-8、TNF-α和hs-CRP水平与54例正常对照组相比明显增高,两组间差异有统计学意义(P均<0.01)。治疗后半个月,在急性炎症缓解后血浆炎性因子基本恢复至正常水平。血浆hs-CRP与IL-1β、IL-6、IL-8和TNF-α水平相关系数分别为0.613 8、0.604 4、0.615 6和0.627 8。结论:急性结膜炎血浆炎性细胞因子在炎症急性期有明显增高。血浆hs-CRP与IL-1β、IL-6、IL-8和TNF-α水平呈正相关。
OBJECTIVE: To observe the changes of plasma inflammatory cytokines in the acute phase of acute conjunctivitis and inflammatory remission. Methods: Radioimmunoassay and hypersensitivity immunoassay were used to determine the plasma levels of interleukin (IL) -1β, IL-6, IL-8, tumor necrosis factor-α and TNF in patients with acute conjunctivitis before and after treatment C-reactive protein (hs-CRP) levels, and compared with the normal control group, the correlation analysis. Results: The levels of IL-1β, IL-6, IL-8, TNF-α and hs-CRP in 127 patients with acute conjunctivitis before and after treatment were significantly higher than those in 54 normal controls, with significant difference between the two groups (P <0.01). Half a month after treatment, plasma inflammatory cytokines returned to normal levels after acute inflammation was relieved. The correlation coefficients of plasma hs-CRP and IL-1β, IL-6, IL-8 and TNF-α levels were 0.613 8,0.604 4,0.615 6 and 0.627 8, respectively. Conclusion: Acute conjunctivitis plasma inflammatory cytokines were significantly increased during the acute phase of inflammation. Plasma hs-CRP was positively correlated with the levels of IL-1β, IL-6, IL-8 and TNF-α.