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目的:探讨硝呋太尔阴道软胶囊辅助治疗阴道炎患者临床疗效。方法:将160例阴道炎患者按照随机数字表法分组为对照组(硝酸咪康唑栓)与治疗组(于对照组治疗基础上采用硝呋太尔阴道软胶囊,放置阴道穹窿部,1粒/次,1次/d),各80例。观察两组患者治疗前后临床症状及性激素水平变化、临床疗效及不良反应,随访2个月,统计两组治愈后复发人数。结果:治疗后,两组患者临床症状均较治疗前明显改善,且观察组改善较对照组显著,P<0.05;治疗后,两组患者性激素(E2、FSH)水平较治疗前明显改善,且观察组改善较对照组更显著,P<0.05。治疗组治疗总有效率92.5%,明显高于对照组67.5%,P<0.05;治疗组治疗期间不良反应率及治愈后复发率均明显低于对照组,P<0.05。结论:应用硝呋太尔阴道软胶囊联合硝酸咪康唑栓治疗阴道炎疗效显著且不良反应少,因此值得推广。
Objective: To investigate the clinical efficacy of nifuratel vaginal soft capsule in the treatment of vaginitis. Methods: 160 cases of vaginitis were randomly divided into the control group (miconazole nitrate suppository) and the treatment group (nifuratel vaginal soft capsule placed on the basis of the control group, placed vaginal fornix, 1 / , 1 time / d), each 80 cases. The changes of clinical symptoms and sex hormone levels before and after treatment in both groups were observed. The clinical efficacy and adverse reactions were observed. The patients were followed up for 2 months. The number of recurrence after treatment was calculated. Results: After treatment, the clinical symptoms of both groups were significantly improved compared with that before treatment, and the improvement in the observation group was more significant than that in the control group (P <0.05). After treatment, the levels of sex hormone (E2 and FSH) in both groups were significantly improved, Observation group improved more significantly than the control group, P <0.05. The total effective rate of the treatment group was 92.5%, which was significantly higher than that of the control group (67.5%, P <0.05). The adverse reaction rate and recurrence rate after treatment in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion: The application of nifuratel vaginal soft capsule combined with miconazole nitrate suppository is effective in treating vaginitis with less adverse reactions, so it is worth popularizing.