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目的研究长期摄取过量的氟对人体胰岛Ｂ细胞功能的影响。方法对暴露组和对照组人群进行Ｘ线检查、尿氟测定、口服葡萄糖耐量试验（ＯＧＴＴ）、血清胰岛素及Ｃ肽释放试验，对其饮用水进行水质分析。结果①暴露组饮水含氟量、尿氟总体几何均数明显高于对照组；②暴露组空腹血糖及服糖后峰值均明显高于对照组，峰值出现时间明显延迟；③暴露组糖尿病、糖耐量减低（ＩＧＴ）的检出率显著高于对照组，暴露组中氟骨症者显著高于非氟骨症者；④暴露组空腹血清胰岛素、Ｃ肽测定值低于对照组，服糖后的峰值明显高于对照组，且峰值明显延迟。结论长期摄取过量的氟对人体胰岛Ｂ细胞功能具有损害作用，且与氟中毒程度呈正相关。
Objective To study the effect of excessive intake of fluoride on human islet B cell function over a long period of time. Methods The exposed group and control group were subjected to X-ray examination, urine fluoride test, oral glucose tolerance test (OGTT), serum insulin and C-peptide release test, and their drinking water quality was analyzed. Results ① The average geometric mean fluoride content and urinary fluoride in drinking water of the exposed group were significantly higher than those of the control group. ② The fasting blood glucose and the peak of post-treatment sugar in the exposed group were significantly higher than those in the control group, and the peak appearance time was significantly delayed. The detection rate of IGT was significantly higher than that of the control group, and the incidence of skeletal fluorosis in the exposed group was significantly higher than that in the non-skeletal fluorosis group. (4) The fasting serum insulin and C-peptide levels in the exposed group were lower than those in the control group The peak was significantly higher than the control group, and the peak was significantly delayed. Conclusion Long-term ingestion of excessive fluoride has a detrimental effect on human pancreatic islet B cell function, and is positively correlated with the degree of fluorosis.