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易栓症是临床常见的多病因疾病，致死致残率高。从遗传性凝血、抗凝纤溶异常的角度去探讨其病因和发病机制，对于该病的预防十分重要。遗传性易栓症包括活化蛋白C抵抗（ APCR）、抗凝血酶缺陷症、蛋白C、蛋白S缺陷症、凝血因子Ⅴ Leiden和凝血酶原G20210A突变等。部分遗传性易栓症患者可能存在蛋白S缺陷和APCR两种缺陷症并存的可能即联合缺陷。该文对蛋白 C、蛋白S、APCR在易栓症中的联合缺陷抗凝体系予以综述。“,”Thrombophilia is a common clinical disease of multiple etiology,with high disability rate and mortality.From the perspectives of hereditary coagulation,anticoagulation and fibrinolysis abnormalities to investigate the etiology and pathogenesis of thrombophilia is very important to the prevention of the disease . Hereditary thrombophilia includes activated protein C resistance(APCR),antithrombin deficiency(AT.Ⅲ), protein C and protein S deficiencies,Factor V Leiden and prothrombin G20210A mutations and so on.There may be joint defects of APCR and protein S deficiency in some cases of hereditary thrombophilia .Here is to make a review of the anticoagulation system of joint defects of protein C,protein S,APCR in thrombophilia.