阿尔茨海默病(AD)的主要特征是淀粉样蛋白沉积(淀粉样斑块),淀粉斑块主要成分是β-淀粉肽(Aβ)Aβ的形成与β-分泌酶有直接关系,而α-分泌酶则可防止Aβ的形成。因此,抑制β-分泌酶和诱导α-分泌酶可能是减少脑中Aβ形成的标靶。作者测试了256种植物和真菌提取物,从裂蹄木层孔菌Phelli-nus linteus Teng菌丝体培养液中分离、鉴定 The main characteristic of Alzheimer’s disease (AD) is amyloid deposition (amyloid plaques). The main component of amyloid plaques is β-amyloid peptide (Aβ). The formation of Aβ is directly related to β-secretase, and α - Secretory enzymes prevent the formation of Aβ. Therefore, inhibition of β-secretase and induction of α-secretase may be the targets of reducing Aβ formation in the brain. The authors tested 256 plant and fungal extracts and isolated and identified from the Mycelium Phelli-nus linteus Teng mycelial culture fluid