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目的:研究蝙蝠葛果提取物(MD)对药物诱发大鼠实验性心律失常和降血压的作用。方法:制备乌头碱、氯化钡(BaCl2)诱发的大鼠实验性心律失常模型,常规测定血压。记录给乌头碱后出现的室早(VA)、室速(VT)、室颤(VF)时的乌头碱用量;记录给BaCl2后心律失常出现时间和维持时间;记录给蝙蝠葛果提取物自身前后血压的变化。结果:MD(40 mg·kg-1 i,v)可明显提高乌头碱诱发大鼠出现室早、室速时的乌头碱用量;MD(40,20 mg·kg-1 i,v)可明显提高大鼠出现室颤时乌头碱用量,可明显推迟氯化钡诱发大鼠心律失常出现时间和缩短维持时间;MD(40 mg·kg-1)降压效果明显,降压持续时间明显延长。结论:MD对2种药物诱发的实验性心律失常均具有明显保护作用,MD有一定降压作用且降压效果明显持久。其抗心律失常机制可能与抑制钙离子、钠离子跨膜流动有关。
Objective: To study the effect of bat pod fruit extract (MD) on drug-induced experimental arrhythmia and blood pressure lowering in rats. Methods: Aconitine and barium chloride (BaCl2) -induced experimental arrhythmia models were established in rats. Blood pressure was measured routinely. Aconitine (VA), VT (ventricular tachycardia) and ventricular fibrillation (VF) were recorded after aconitine injection. The time and maintenance time of arrhythmia recorded after BaCl2 treatment were recorded. Changes in blood pressure before and after the thing itself. Results: Aconitine (MD, 40, 20 mg · kg-1 i, v) was significantly increased when MD (40 mg · kg-1 i, v) Can significantly improve the rat aconitum when the amount of ventricular fibrillation, can significantly delay barium chloride-induced arrhythmia and shorten the duration of maintenance; MD (40 mg · kg-1) antihypertensive effect, duration of antihypertensive Significantly longer. Conclusion: MD has significant protective effect on two kinds of drug-induced experimental arrhythmia. MD has a certain antihypertensive effect and antihypertensive effect is obvious and lasting. Its anti-arrhythmic mechanism may be related to the inhibition of calcium and sodium ion transmembrane flow.