随着细胞生物学的发展,软骨细胞体外培养的研究日益深入,细胞因子参与调节软骨细胞的增殖、分化过程逐渐被人们所揭示。目前,已确知有许多细胞因子具有促进软骨细胞增生、分化的作用,包括成纤维细胞生长因子(FGF)。转化生长因子(TGF-β)、胰岛素样生长因子(IGF)及血小板衍生生长因子(PDGF)等,其中FGF作用最为广泛。但是,目前这 With the development of cell biology, the in vitro culture of chondrocytes has been further studied. Cytokines are involved in the regulation of proliferation and differentiation of chondrocytes. At present, many cytokines are known to promote the proliferation and differentiation of chondrocytes, including fibroblast growth factor (FGF). Transforming growth factor (TGF-β), insulin-like growth factor (IGF) and platelet derived growth factor (PDGF), among which FGF has the most extensive effect. But this is the current